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Peter Oosterhuis, a British golfer who won 20 tournaments around the world, played in the Ryder Cup six times and later distinguished himself as a commentator for CBS and Golf Channel, died on Thursday in Charlotte, N.C. His wife, Ruth Ann (DuClos) Oosterhuis, said that his death, at a memory care facility, was caused by complications of Alzheimer’s disease. That year, Oosterhuis (pronounced OH-ster-house) spoke to Golf Digest about his life and career. One detailed memory he still had: “In the 1973 Ryder Cup, I played Lee Trevino in one of my singles matches. Lee told his teammates, ‘If I don’t beat Oosterhuis, I’ll come in here and kiss your butts.’ Lee didn’t beat me.”
Persons: Peter Oosterhuis, Ruth Ann, Oosterhuis, , , Lee Trevino, Lee, I’ll, ’ Lee didn’t Organizations: Ryder, CBS, Golf, Digest Locations: British, Charlotte, N.C
Scientists identify ‘degrees of Kevin Bacon’ gene
  + stars: | 2024-05-02 | by ( Katie Hunt | ) edition.cnn.com   time to read: +6 min
Even humble fruit flies organize themselves into regularly spaced clusters, researchers have found. Within those social networks, certain individuals will often stand out as “gatekeepers,” playing an important role for cohesion and communication within that group. New research published Tuesday in the journal Nature Communications has identified a gene responsible for regulating the structure of social networks in fruit flies. The study opened up new opportunities for exploring the molecular evolution of social networks and collective behavior in other animals. FLPA/ShutterstockThe gene behind fruit fly social networksThe researchers investigated a number of gene candidates in fruit flies, a common lab organism used in the study of genetics.
Persons: , Kevin Bacon, Bacon, Joel Levine, Rebecca Rooke, ” Levine, Levine, , ” Allen J, Moore, wasn’t, ” Moore Organizations: CNN, Nature Communications, University of Toronto, University of Georgia’s Locations: Philadelphia, University of Toronto Mississauga
Robert B. Oxnam, an eminent China scholar who learned through psychotherapy that his years of erratic behavior could be explained by the torment of having multiple personalities, died on April 18 at his home in Greenport, N.Y., on the North Fork of Long Island. In the 1ate 1980s, Dr. Oxnam was president of the Asia Society, a television commentator and an accomplished sailor. In his 2005 book, “A Fractured Mind: My Life With Multiple Personality Disorder,” Dr. Oxnam recalled the session when Tommy first spoke to Dr. Smith. All that Dr. Oxnam could remember from the 50-minute session, he wrote, was telling the psychiatrist that he didn’t think the therapy was working for him. But Dr. Smith told him that he had been speaking to Tommy all that time.
Persons: Robert B, Vishakha Desai, Oxnam, Jeffery Smith, Bobby, Tommy, Smith Organizations: Asia Society Locations: China, Greenport, Long
“If we work with our physiology knowing that women are women and men are men, knowing that women are not small men, then imagine the (health) outcomes,” she said at a 2019 TED talk. Women of all ages should focus on strength training to help reduce risk of dementia, said exercise physiologist and nutrition scientist Dr. Stacy Sims (not shown). Dr. Stacy Sims said women should prioritize eating more protein to support building muscle, especially as bodies age. But if we have that lean mass from strength training, it really helps calm down that rate of change. Drinking something cold right after exercise helps bring that blood back centrally, reduces metabolites and starts the reparation process.
Persons: Joe Biden, , Stacy Sims, , MoMo, Sims, Darwin, that’s, Alzheimer’s, haven’t, It’s, , Melanie Radzicki McManus Organizations: CNN’s, CNN, TED, National Institutes of Health, Women’s, US National Institutes of Health Locations: Mount Maunganui , New Zealand
Sandra TorresTorres has a rare disorder called Laron syndrome that is caused by a genetic mutation. “This is how powerful this mutation seems to be.”What is Laron syndrome? Laron syndrome is a recessive gene, so only those who receive a copy from each parent will be affected. The condition leads to extreme obesity, a trigger for diabetes, heart disease, cancer and other diseases. While technically overweight at 100 pounds (45.4 kilograms), she was in good health, with no signs of diabetes or heart disease.
Persons: Paola Castro Torres, ” Torres, Torres, , ” Nathaly Paola Castro Torres, Sandra Torres Torres, , Valter Longo, Longo, Laron, Jaime Guevara, Aguirre, Guevara, ” Longo, ” Guevara, Andrew Freeman, Freeman, ” Hope, it’s Organizations: CNN, gerontology, University of Southern, of Endocrinology, Laron, Jewish Health Locations: Los Angeles, Quito, Ecuador, University of Southern California, Israel, Yemen, East, United States, Croatia, Ireland, Denver
Last year was called the year of Ozempic, though it was also a year of Ozempic backlash and Ozempic shortages, which could persist for years. Even so, we appear very far from a peak for GLP-1 drugs, like Ozempic and Wegovy, which are powered by a molecule called semaglutide, and Mounjaro, which uses its cousin tirzepatide. It seems possible to imagine a future in which almost everyone is taking some variety of GLP-1 drug, and with a pretty good reason to do so. Patients on Ozempic and Wegovy can lose 15 to 20 percent or more of their weight in a little over a year, and if they stay on the drugs, the weight tends to stay off. Semaglutide has been shown to eliminate or reduce the need for insulin among those with recent-onset Type 1 diabetes.
Persons: tirzepatide, Wegovy, we’ve, Semaglutide Locations: Alzheimer’s
Having a routine job with little mental stimulation during your 30s, 40s, 50s and 60s was linked to a 66% higher risk of mild cognitive impairment and a 37% greater risk of dementia after the age of 70, according to the study, when compared with having a job with high cognitive and interpersonal demands. Attending college, for example, reduced the impact of a repetitive job by about 60% but didn’t fully negate the risk. Routine jobs that were not classified as “cognitively protective” often involved repetitive manual and mental tasks, such as is typical of factory work and bookkeeping. “Most people in routine jobs in our sample included housekeepers, custodians, construction workers and mail carriers,” Edwin said. More cognitively demanding jobs were not based on routine tasks, even though repetition was required at times.
Persons: , Dr, Trine Edwin, Edwin said, Richard Isaacson, Isaacson, ” Edwin, Edwin, It’s, ” Isaacson Organizations: CNN, Oslo University Hospital, American Academy of Neurology, Locations: Norway, Florida
In 1817, James Parkinson expressed a hope about the disease that is named after him. He thought that at some point there would be a discovery and “the progress of the disease may be stopped.”Now, nearly 200 years since Parkinson expressed his hope, and after four decades of unsuccessful clinical trials, a group of French researchers reports the first glimmer of success — a modest slowing of the disease in a one-year study. And the drug they used? A so-called GLP-1 receptor agonist, similar to the wildly popular drugs Ozempic, for diabetes, and Wegovy, for obesity. As many as half a million Americans have been diagnosed with Parkinson’s disease, a degenerative brain illness second only to Alzheimer’s in prevalence.
Persons: James Parkinson, Parkinson
Betty Cole Dukert, who began her career in Washington as a secretary in the 1950s and later became the top producer of the weekly NBC News public affairs program “Meet the Press,” died on March 16 at her home in Bethesda, Md. Her late husband’s niece Barbara Dukert Smith said the cause was complications of Alzheimer’s disease. “She was the main point of contact on Capitol Hill for the show,” said Betsy Fischer Martin, who started on “Meet the Press” as an intern and became the program’s executive producer in 2002. “She worked the phones constantly. It wasn’t an era when you could send off an email to book someone.”
Persons: Betty Cole Dukert, , Barbara Dukert Smith, Dukert, Betsy Fischer Martin, Organizations: NBC News, Press, , NBC, Capitol Locations: Washington, Bethesda, Md
“Science postdocs perform the science,” Donna Ginther, an economist who studies the science labor market at the University of Kansas, told CNN. Biomedical companies take scientific contributions and, over time, aggregate them into a commercial product. Building on the discovery of mRNA in the 1960’s, the technology behind an mRNA vaccine for humans was in development for decades before the Covid-19 vaccine was first administered in 2020. By using that technology to develop their mRNA vaccines for Covid-19, pharmaceutical companies like Pfizer and Moderna made a windfall in profits. “That’s how they make money is through commercialization: they have a product, which they then patent and sell.”Why are scientists leaving academic labs?
Persons: postdocs, Donna Ginther, “ They’re, Michael Ciaglo, , , Nobel, Dr, Katalin Kariko, ” Ginther, they’re, Ginther Organizations: New, New York CNN —, National Institutes of Health, NIH, National Science Foundation, University of Kansas, CNN, , Pfizer, Moderna, Wired Magazine, NSF, World Health Organization Locations: New York, United States, Denver , Colorado, Europe, Alzheimer’s
Giandomenico Picco, an Italian diplomat who as a lead negotiator for the United Nations helped resolve conflicts across the globe — most notably spending nearly a year in the early 1990s shuttling around the Middle East to secure the release of 11 hostages held by terrorist groups in Lebanon — died on Sunday in Wilton, Conn., north of Norwalk. His son Giacomo said the cause of his death, at an assisted living home, was complications of Alzheimer’s disease. Mr. Picco spent 20 years with the U.N., mostly in a series of loosely defined roles that placed him at the center of some of the world’s most dangerous hot spots. Early in his career he helped manage the conflict between Greece and Turkey over the island of Cyprus; in 1986 he mediated between New Zealand and France after French secret agents sank the Rainbow Warrior, a Greenpeace ship, in the Auckland harbor; and in 1988 he helped arrange the Soviet withdrawal from Afghanistan.
Persons: Giandomenico Picco, Lebanon —, Giacomo, Picco Organizations: United Nations, Greenpeace Locations: Italian, Lebanon, Wilton, Conn, Norwalk, Greece, Turkey, Cyprus, New Zealand, France, Auckland, Afghanistan
The Food and Drug Administration has decided to delay action on a closely watched Alzheimer’s drug, donanemab, which the agency was widely expected to approve this month. will instead require donanemab to undergo the scrutiny of a panel of independent experts, the drug’s maker, Eli Lilly and Company, said Friday. The decision is likely to surprise many Alzheimer’s experts, doctors and patients who had expected the medication would soon be on the market. The F.D.A.’s move was startling to the company, which had been planning for the agency to greenlight the drug during the first quarter of this year. “We were not expecting this,” Anne White, an executive vice president of Lilly and president of its neuroscience division, said in an interview.
Persons: Eli Lilly, , Lilly, ” Anne White, Organizations: Drug Administration Locations: donanemab
The Dells contributed nearly $976 million to their charitable funds, which distribute gifts to a wide array of charities. Together, the 50 donors on the list contributed a total of $11.9 billion to charity in 2023. Only 23 of the richest Americans on the Forbes 400 list donated enough to appear on the Philanthropy rankings. 13 on the list, they contributed $210 million to the Institute for Protein Innovation, which shares its data with scientists for free. _____Maria Di Mento is a senior reporter and Jim Rendon is a senior writer at the Chronicle of Philanthropy, where you can read the full article.
Persons: Michael Bloomberg, Phil Knight, Penny, Michael Dell, Susan, Bill Gates, Melinda French Gates, Bernie Marcus, Ken Langone, Arthur Blank, , , Renee Kaplan, — Franklin Antonio, Hugh Hoffman, , Tim Springer, Chafen Lu, Diego’s Jay Kahn, Lauder, Sergey Brin’s, Michael J, Robert Kraft, Lucia Woods, David, Kathleen LaCross, Pierre Omidyar, Pam, They’re, John, Laura Arnold, Laura, ” Laura Arnold, Wendy Schmidt, Eric Schmidt, “ Younger, Kaplan, Jeff Sobrato, _____ Maria Di Mento, Jim Rendon, Kay Dervishi Organizations: New, New York City, Nike, Bloomberg, Knights, University of Oregon, Dells, Forbes, Forward, Qualcomm, Summer Science, SETI Institute, ALS Association , University of Cincinnati Foundation, Cincinnati Zoo, Botanical, Nature Center, Yale University, Institute for Protein Innovation, Price Club, Apple, San Diego Foundation, Discovery Foundation, Google, Fox Foundation, Parkinson’s Research, New England Patriots, Foundation, Combat, Ms, Foundation for Women, Chicago Foundation for Women, University of Virginia Darden School of Business, eBay, District of Columbia, Associated Press, Philanthropy Locations: New York, Portland , Oregon, Ohio, Moderna, California, Florida, Texas, Virginia, Washington, Hawaii, Massachusetts
The choice she faces — promoting her husband’s political ambitions or protecting his legacy — can no longer be avoided. Having worked closely with Nancy Reagan during her husband’s first term, and seeing how she weighed choices like this one, I’ve found myself wondering if Mrs. Reagan were in Dr. Biden’s position, what advice would she have given to Ronald Reagan? Mr. Reagan and Mr. Biden’s legacies hung in the balance because of issues related to age. Mr. Biden’s age has clearly become a burden for his re-election prospects. Mrs. Reagan’s backing extended even to urging her husband to stand up to his powerful ideological advisers.
Persons: Lady Jill Biden, Nancy Reagan, I’ve, Reagan, Biden’s, Ronald Reagan, Nancy, Reagan’s, Walter Mondale, , Biden Organizations: ABC Locations: Soviet Union
Apparently Healthy, but Diagnosed With Alzheimer’s?
  + stars: | 2024-03-04 | by ( Paula Span | ) www.nytimes.com   time to read: 1 min
Determining whether someone has Alzheimer’s disease usually requires an extended diagnostic process. A doctor takes a patient’s medical history, discusses symptoms, administers verbal and visual cognitive tests. or a spinal tap — tests that detect the presence of two proteins in the brain, amyloid plaques and tau tangles, both associated with Alzheimer’s. All of that could change dramatically if new criteria proposed by an Alzheimer’s Association working group are widely adopted. Its final recommendations, expected later this year, will accelerate a shift that is already underway: from defining the disease by symptoms and behavior to defining it purely biologically — with biomarkers, substances in the body that indicate disease.
Organizations: Alzheimer’s Association
Tel Aviv, Israel CNN —The UN agency for Palestinian refugees on Monday accused Israel of detaining and torturing some of its staffers, coercing them into making false confessions about the agency’s ties to Hamas. “Some of our staff have conveyed to UNRWA teams that they were forced to (make) confessions under torture and ill-treatment. These false confessions were in response to questioning about relations between UNRWA and Hamas and involvement in the 7 October attack against Israel,” UNRWA spokeswoman Juliette Touma said in a statement. UNRWA estimates that at least 4,000 Gazans have been detained by the Israeli military since the start of the war. According to the UNRWA report, some detainees reported being stripped, handcuffed and held in the cold with no access to toilets, food or water for over 24 hours.
Persons: Israel, Juliette Touma, Touma, Organizations: Israel CNN —, UN, UNRWA, UN Relief and Works Agency of, CNN, Agency, New York Times Locations: Tel Aviv, Israel, Gaza
CNN —Bruce Willis’ wife has hit out at an online report that “there is no more joy” in her husband’s life. Emma Heming Willis said in a video posted to her Instagram profile on Sunday that she had been “clickbaited” by a headline “to do with my own family.”Appearing angry and frustrated, Heming Willis said she had been “triggered” by the story, which she came across on Sunday morning. Love is a beautiful thing ❤️ Wishing you all a Happy Valentine’s Day 🫶🏽 Emma Heming Willis/InstagramIn an interview last year, Heming Willis admitted that the diagnosis had been tough on her husband, herself and their two daughters. “What I’m learning is that dementia is hard,” Heming Willis told Hoda Kotb on the Today show on NBC. And that is no different for Bruce or myself or our girls.”That said, in a written message accompanying her video, Heming Willis explained that there was a lot more to the family’s situation than many headlines suggest.
Persons: Bruce Willis ’, Emma Heming Willis, , Heming Willis, Willis, Organizations: CNN, Alzheimer’s Research Locations: FTD
ATLANTA (AP) — Since Jimmy Carter entered hospice care at his home in south Georgia one year ago, the former U.S. president has celebrated his 99th birthday, enjoyed tributes to his legacy and lost his wife of 77 years. Those advocates commend the Carter family for demonstrating the realities of aging, dementia and death. Almost half of Medicare patients who died that year did so under hospice care. JIMMY CARTER’S ENDURANCE IS NOT UNUSUALIn 2021, the average stay of hospice patients who died was 92 days, MedPAC calculated. About 10% of enrollees who die in hospice care stayed more than 264 days.
Persons: Jimmy Carter, Rosalynn Carter, Carter, “ It’s, , Angela Novas, it’s, , Mollie Gurian, ” Gurian, Gurian, Chip Carter, Jimmy, Rosalynn, Novas, JIMMY CARTER’S, , Jimmy Carter’s, JIMMY CARTER, ” Novas Organizations: ATLANTA, Hospice Foundation of America, Medicare, Advisory, Novas, The Washington Post Locations: Georgia, Washington, Plains, U.S,
Japan’s Nikkei hits 34-year high
  + stars: | 2024-02-13 | by ( ) edition.cnn.com   time to read: +2 min
Tokyo Reuters —Japan’s Nikkei share average closed at a fresh 34-year high on Tuesday as trading resumed after a long holiday weekend, with tech-related shares and strong corporate earnings supporting the benchmark stock index. The Nikkei climbed 2.89% to 37,963.97 to its highest since January 1990, after briefly breaching 38,000 points. The broader Topix rose 2.12%. Among other top gainers, Tokio Marine Holdings Inc and MS&AD Insurance Group Holdings Inc gained 11% and 10.82%, respectively. As the Nikkei climbs toward its all-time high, the US consumer price index (CPI) report out later on Tuesday will be in focus.
Persons: SoftBank, , ” JP Morgan, , Charu Chanana Organizations: Tokyo Reuters, Japan’s Nikkei, Nikkei, Tokyo, SoftBank, ARM Holding, Tokio Marine Holdings Inc, Insurance, Holdings, CPI, Saxo Markets, Otsuka Holdings Locations: Tokyo
How to fight dementia, according to neurologists
  + stars: | 2024-02-12 | by ( Sandee Lamotte | ) edition.cnn.com   time to read: +17 min
What about diabetes, cancer, thyroid disease, high blood pressure or heart disease? Some of the questions might seem unexpected to those who don’t write about brain health. However, my risk of developing vascular dementia, the second most common type after Alzheimer’s disease, is elevated. "Such spikes cause brain inflammation, disrupt brain metabolism and increase shrinkage of the thinking part of the brain," Isaacson said. The National Institute on Aging currently supports nearly 500 active clinical trials on Alzheimer’s disease and related dementias.
Persons: Louise Dittner, Krysta, Ryan LaMotte, It’s, , Natalia Rost, , Rost, ” Rost, Richard Isaacson, ” Isaacson, mockingbird …, birthed, it’s, I’ve, Isaacson, Sandee LaMotte Organizations: CNN, Comprehensive, Massachusetts General Hospital, Harvard Medical School, American Academy of Neurology, Boca Raton, Weill Cornell Medicine, Presbyterian, Mayo Clinic, Volunteers, Alzheimer’s, National Institute on Aging, National Institutes of Health Locations: Massachusetts, Boston, neonatologists, Florida, United, New York, New York City, Nature
The night before my father died, Ronald Reagan, I listened to his breathing — ragged, thin. Or of the man who lifted his voice to the overcast sky and said, “Mr. Long before my father ran for office, politics sat between us at the dinner table. The conversations were predictable: Big government was the problem, the demon, the thing America had to be wary of. I wanted to talk about the boy who bullied me on the school bus, not government overreach.
Persons: Ronald Reagan, “ Mr, Gorbachev, Long Organizations: America
How we change as we ageA decline in cognitive abilities is a normal part of healthy aging, said Dr. Emily Rogalski, Rosalind Franklin Professor of Neurology at the University of Chicago. A diagnosis of mild cognitive impairment is made clinically when cognitive difficulties become frequent and fall outside what is considered normal aging. “There’s not a whole lot of good evidence that there’s anything special about age 80 that leads to a drop-off” in cognitive abilities, Mather said. And they use cognitive tests, such as the Mini Mental Status Exam (MMSE) or Montreal Cognitive Assessment (MOCA), to assess performance in different cognitive areas. Although population-level data associates aging with cognitive decline, the actual manifestation of aging is very diverse on an individual level, Rogalski said.
Persons: Joe Biden, Donald Trump, Biden, Trump, Nikki Haley, Nancy Pelosi, Emily Rogalski, Rosalind Franklin, , Molly Mather, , Angela Roberts, Roberts, “ There’s, Mather, MMSE, We’re, ” Mather, Nir Barzilai, Rogalski, “ We’ve, superagers, Barzilai, “ It’s, Dr, Sanjay Gupta, ” Roberts Organizations: CNN, House, Republican, NBC, Neurology, University of Chicago, UCSF, Aging, Northwestern University’s Feinberg School of Medicine, National Institute, Western University, Institute for Aging Research, Albert Einstein College of Medicine, American Federation for Aging Research, Trump, Biden, Get CNN, CNN Health, Locations: Mexico, Egypt, Montreal
CNN —The extraordinary discovery of a decades-old message in a bottle has inspired alumni of a Long Island, New York, high school to remember their beloved late science teacher. Merci, Gracias, Danke, Thank you, Shawn and Ben,” the letter read, addressed from Mattituck High School on Long Island in October 1992. Courtesy Adam TravisAmazement and wonder bubbled up in the Mattituck High School Alumni Facebook group about how the letter remained intact for 32 years – and how it was found just a few miles from the high school. “The message in a bottle project was one of his favorite and longest-standing projects over the years,” Brooks said. Earth science teacher Richard E. Brooks often assigned the "message in a bottle project," his son said.
Persons: Adam Travis, , ” Travis, Travis didn’t, Shawn, Ben, Richard E, Brooks, “ Mr, , Benny Doroski, ” Brooks ’, John, John Brooks, ” Brooks, Brooks ’ Organizations: CNN, Mattituck High, Facebook, Mattituck High School Locations: , New York, Shinnecock Bay, Long, Alzheimer’s, Azores, Ireland,
Eli Lilly rode soaring demand for diabetes and weight-loss treatments to a better-than-expected finish in 2023, and the drugmaker expects momentum to carry into the new year. Lilly said on Tuesday that revenue could climb as much as 22% this year, as star sellers like the diabetes drug Mounjaro and its new weight-loss counterpart, Zepbound, gain market share. Mounjaro sales jumped 65% to $2.21 billion in the fourth quarter compared with the third quarter. Doctors also prescribe that drug off-label for weight loss, which is one of the hottest areas of pharmaceutical sales. The share price for Indianapolis-based Eli Lilly and Co. has climbed over 400% since the start of the decade.
Persons: Eli Lilly, Lilly, Doctors, David Ricks, , , FactSet, donanemab Organizations: Company, Revenue, Drug Administration, Indianapolis Locations: Mounjaro, North Carolina
CNN —Living a healthy lifestyle with a focus on a nutritious diet, regular exercise, minimum alcohol consumption and other healthy habits can help keep your brain sharp into old age, doctors say. But what if your brain already has signs of beta amyloid or tau — two of the hallmark signs of Alzheimer’s and other brain pathologies? Will a healthy lifestyle still protect you from cognitive decline? Not everyone who has signs of Alzheimer’s or vascular dementia goes on to develop cognitive issues, but many do. In fact, “a higher healthy lifestyle score was associated with better cognition even after accounting for the combined burden of brain pathologies,” according to Yaffe and Leng.
Persons: , Dr, Klodian, Richard Isaacson, , Isaacson, wasn’t, , Kobus, Lewy, Yue Leng, Kristine Yaffe, Yaffe, San Francisco Weill Institute for Neurosciences . Leng, Leng, it’s Organizations: CNN, Rush Institute, Healthy Aging, Rush University, , University of California, San Francisco Weill Institute for Neurosciences . Locations: Chicago, Florida, San
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